American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Aug 2014
Randomized Controlled Trial Clinical TrialAcute outcomes and 1-year mortality of ICU-acquired weakness: A cohort study and propensity matched analysis.
Intensive care unit (ICU)-acquired weakness is a frequent complication of critical illness. It is unclear whether it is a marker or mediator of poor outcomes. ⋯ After careful matching the data suggest that ICU-acquired weakness worsens acute morbidity and increases healthcare-related costs and 1-year mortality. Persistence and severity of weakness at ICU discharge further increased 1-year mortality. Clinical trial registered with www.clinicaltrials.gov (NCT 00512122).
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Am. J. Respir. Crit. Care Med. · Aug 2014
Gender-dependent Influence of Endogenous Estrogen in Pulmonary Hypertension.
The incidence of pulmonary arterial hypertension is greater in women, suggesting estrogens may play a role in the disease pathogenesis. Experimentally, in males, exogenously administered estrogen can protect against pulmonary hypertension (PH). However, in models that display female susceptibility, estrogens may play a causative role. ⋯ The unique phenotype of female pulmonary arteries facilitates the therapeutic effects of anastrozole in experimental PH confirming a role for endogenous estrogen in the disease pathogenesis in females and suggests aromatase inhibitors may have therapeutic potential.