American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Oct 2015
Randomized Controlled TrialFirst Human Challenge Testing of a Pneumococcal Vaccine - Double Blind Randomised Controlled Trial.
New vaccines are urgently needed to protect the vulnerable from bacterial pneumonia. Clinical trials of pneumonia vaccines are slow and costly, requiring tens of thousands of patients. Studies of pneumococcal vaccine efficacy against colonization have been proposed as a novel method to down-select between vaccine candidates. ⋯ 45340436.