American journal of respiratory and critical care medicine
-
Am. J. Respir. Crit. Care Med. · Jun 2015
A Sex-specific MicroRNA-96/5HT1B Axis Influences Development of Pulmonary Hypertension.
Females are predisposed to pulmonary arterial hypertension (PAH); evidence suggests that serotonin, mutations in the bone morphogenetic protein receptor (BMPR) II gene, and estrogens influence development of PAH. The 5-hydroxytryptamine 1B receptor (5-HT1BR) mediates human pulmonary artery smooth muscle cell (hPASMC) proliferation. ⋯ Increased 5-HT1BR expression may be a consequence of decreased miRNA-96 expression in female patient PASMCs, and this may contribute to the development of PAH.