American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Jun 2015
Randomized Controlled Trial Multicenter StudyBudesonide/Formoterol for Bronchiolitis Obliterans After Hematopoietic Stem Cell Transplantation.
Systemic steroids are the standard treatment for bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic stem cell transplantation (HSCT) despite their poor efficacy and disabling side effects. ⋯ Budesonide/formoterol administration led to a significant improvement in the FEV1 in patients with mild/severe BOS after allogeneic HSCT. Clinical trial registered with www.clinicaltrials.gov (NCT00624754).
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Am. J. Respir. Crit. Care Med. · Jun 2015
Practice GuidelineAn Official ATS/AACN/ACCP/ESICM/SCCM Policy Statement: Responding to Requests for Potentially Inappropriate Treatments in Intensive Care Units.
There is controversy about how to manage requests by patients or surrogates for treatments that clinicians believe should not be administered. ⋯ The multisociety statement on responding to requests for potentially inappropriate treatments in intensive care units provides guidance for clinicians to prevent and manage disputes in patients with advanced critical illness.