American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Jan 2016
Outcomes of Childhood Asthma and Wheezy Bronchitis - a 50-year Cohort Study.
Cohort studies suggest that airflow obstruction is established early in life, manifests as childhood asthma and wheezy bronchitis, and continues into early adulthood. Although an association between childhood asthma and chronic obstructive pulmonary disease (COPD) in later life has been demonstrated, it is unclear if childhood wheezy bronchitis is associated with COPD. ⋯ Childhood wheezy bronchitis and asthma are associated with an increased risk of COPD and reduced ventilatory function.
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Am. J. Respir. Crit. Care Med. · Jan 2016
PGI2 Signaling Inhibits Group 2 Innate Lymphoid Cell Responses.
Group 2 innate lymphoid cells (ILC2s) robustly produce IL-5 and IL-13, cytokines central to the asthma phenotype; however, the effect of prostaglandin (PG) I2 on ILC2 function is unknown. ⋯ These results suggest that PGI2 may be a potential therapy to reduce the ILC2 response to protease-containing aeroallergens, such as Alternaria.