American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Mar 2017
Comparative StudyMicroCT Comparison of Preterminal Bronchioles in Centrilobular and Panlobular Emphysema.
Very little is known about airways that are too small to be visible on thoracic multidetector computed tomography but larger than the terminal bronchioles. ⋯ These results provide new information about small airways pathology in centrilobular and panlobular emphysema and show that these changes affect airways that are not visible with thoracic multidetector computed tomography scans but located proximal to the terminal bronchioles in chronic obstructive pulmonary disease.
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Am. J. Respir. Crit. Care Med. · Mar 2017
Randomized Controlled Trial Multicenter StudyBenefits of Long-Term Pulmonary Rehabilitation Maintenance Program in Severe COPD Patients: 3 Year Follow-Up.
In chronic obstructive pulmonary disease (COPD), the benefits of pulmonary rehabilitation (PR) tend to wane over time. Whether maintenance techniques may help sustain the benefits achieved after completion of the initial PR program remains controversial. ⋯ This study shows a 2-year beneficial effect of a program of rehabilitation maintenance on the BODE index and 6MWD when compared with a standard strategy. This effect vanishes after the second year of follow-up. Clinical trial registered with www.clinicaltrials.gov (NCT 01090999).
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Am. J. Respir. Crit. Care Med. · Mar 2017
Asthma Trajectories in a Population-based Birth Cohort: Impacts of Air Pollution and Greenness.
The heterogeneity of asthma phenotypes may explain inconsistencies in observed associations with environmental exposures. ⋯ Traffic-related air pollution increased the probability of a chronic asthma trajectory.
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Am. J. Respir. Crit. Care Med. · Mar 2017
Relationships Among Maternal Stress and Depression, Type 2 Responses, and Recurrent Wheezing at Age 3 Years in Low Income Urban Families.
Maternal depression and prenatal and early life stress may influence childhood wheezing illnesses, potentially through effects on immune development. ⋯ In urban children at high risk for asthma, maternal perceived stress and depression were significantly associated with recurrent wheezing but not increased atopy or reduced antiviral responses.