American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Mar 2017
ReviewCarbon Monoxide Poisoning: Pathogenesis, Management and Future Directions of Therapy.
Carbon monoxide (CO) poisoning affects 50,000 people a year in the United States. The clinical presentation runs a spectrum, ranging from headache and dizziness to coma and death, with a mortality rate ranging from 1 to 3%. A significant number of patients who survive CO poisoning suffer from long-term neurological and affective sequelae. ⋯ Although hyperbaric oxygen significantly reduces the permanent neurological and affective effects of CO poisoning, a portion of survivors still have substantial morbidity. There has been some early success in therapies targeting the downstream inflammatory and oxidative effects of CO poisoning. New methods to directly target the toxic effect of CO, such as CO scavenging agents, are currently under development.
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Am. J. Respir. Crit. Care Med. · Mar 2017
Preeclampsia Associates with Asthma, Allergy and Eczema in Childhood.
Preeclampsia reflects an unusual increase in systemic inflammation during pregnancy. ⋯ Preeclampsia is a shared prenatal risk factor for asthma, eczema, and allergy in childhood pointing toward in utero immune programming of the child.