American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Dec 2018
End-of-Life Strategies among Patients with Advanced Chronic Obstructive Pulmonary Disease.
The burden of advanced chronic obstructive pulmonary disease (COPD) is high globally; however, little is known about how often end-of-life strategies are used by this population. ⋯ The proportion of people with advanced COPD using end-of-life strategies, although increasing, remains low. Efforts should focus on increasing access to such strategies and educating patients and providers of their benefits.
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Am. J. Respir. Crit. Care Med. · Dec 2018
Ontogeny and Biology of Human Small Airway Epithelial Club Cells.
Little is known about human club cells, dome-shaped cells with dense cytoplasmic granules and microvilli that represent the major secretory cells of the human small airways (at least sixth-generation bronchi). ⋯ These observations provide novel insights into the molecular phenotype and biologic functions of the human club cell population and identify basal cells as the human progenitor cells for club cells.