American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Jan 2018
Randomized Controlled Trial Multicenter Study Comparative StudyEffects of a Telephone- and Web-based Coping Skills Training Program Compared to an Education Program for Survivors of Critical Illness and Their Family Members: A Randomized Clinical Trial.
Many survivors of critical illness and their family members experience significant psychological distress after patient discharge. ⋯ CST did not improve psychological distress symptoms compared with an education program. However, CST improved symptoms of distress at 6 months among patients with high baseline distress, whereas the education program improved distress at 3 months among those ventilated for more than 7 days. Future efforts to address psychological distress among critical illness survivors should target high-risk populations. Clinical trial registered with www.clinicaltrials.gov (NCT01983254).
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Am. J. Respir. Crit. Care Med. · Jan 2018
Randomized Controlled Trial Multicenter StudyA Phase 2 Randomized Controlled Study of Tralokinumab in Subjects with Idiopathic Pulmonary Fibrosis.
IL-13 is a potential therapeutic target for idiopathic pulmonary fibrosis (IPF); preclinical data suggest a role in tissue fibrosis, and expression is increased in subjects with rapidly progressing disease. ⋯ Tralokinumab demonstrated an acceptable safety and tolerability profile but did not achieve key efficacy endpoints. Clinical trial registered with www.clinicaltrials.gov (NCT01629667).
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Am. J. Respir. Crit. Care Med. · Jan 2018
Comparative Study Controlled Clinical TrialWeight-adjusted Intravenous Reslizumab in Severe Asthma with Inadequate Response to Fixed-dose Subcutaneous Mepolizumab.
Clinical benefits of fixed-dose 100-mg subcutaneous (SC) mepolizumab in prednisone-dependent patients are modest when sputum eosinophilia is not adequately controlled. ⋯ Weight-adjusted IV reslizumab was superior to fixed-dose SC mepolizumab in attenuating airway eosinophilia in prednisone-dependent patients with asthma, with associated improvement in asthma control. Clinical trial registered with www.clinicaltrials.gov (NCT 02559791).
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Am. J. Respir. Crit. Care Med. · Jan 2018
Randomized Controlled TrialEffect of Telemedicine Education and Telemonitoring on CPAP Adherence: The Tele-OSA Randomized Trial.
Automated telemedicine interventions could potentially improve adherence to continuous positive airway pressure (CPAP) therapy. ⋯ The use of CPAP telemonitoring with automated feedback messaging improved 90-day adherence in patients with OSA. Telemedicine-based education did not significantly improve CPAP adherence but did increase clinic attendance for OSA evaluation. Clinical trial registered with www.clinicaltrials.gov (NCT02279901).