American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Apr 2018
Letter Randomized Controlled Trial Comparative StudyGastric Banding Surgery versus CPAP for Obstructive Sleep Apnea: A Randomized Controlled Trial.
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Am. J. Respir. Crit. Care Med. · Apr 2018
Novel Method for Noninvasive Sampling of the Distal Airspace in Acute Respiratory Distress Syndrome.
A major barrier to a more complete understanding of acute respiratory distress syndrome (ARDS) pathophysiology is the inability to sample the distal airspace of patients with ARDS. The heat moisture exchanger (HME) filter is an inline bacteriostatic sponge that collects exhaled moisture from the lungs of mechanically ventilated patients. ⋯ These data suggest that HMEF is a novel, noninvasive method to accurately sample the distal airspace in patients with ARDS.
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Am. J. Respir. Crit. Care Med. · Apr 2018
Depletion of Airway Submucosal Glands and TP63+KRT5+ Basal Cells in Obliterative Bronchiolitis.
Obliterative bronchiolitis (OB) is a major cause of mortality after lung transplantation. Depletion of airway stem cells (SCs) may lead to fibrosis in OB. ⋯ SMGs and basal SC compartments are depleted in large and/or small airways of lung allografts, and basal SC proliferative capacity declines with progression of disease and phenotypic changes. Global airway SC depletion may be a mechanism for pulmonary allograft failure.
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Am. J. Respir. Crit. Care Med. · Apr 2018
Esophageal Manometry and Regional Transpulmonary Pressure in Lung Injury.
Esophageal manometry is the clinically available method to estimate pleural pressure, thus enabling calculation of transpulmonary pressure (Pl). However, many concerns make it uncertain in which lung region esophageal manometry reflects local Pl. ⋯ These data support the use of esophageal manometry in acute respiratory distress syndrome. Assuming correct calibration, expiratory Pl derived from Pes reflects Pl in dependent to middle lung, where atelectasis usually predominates; inspiratory Pl estimated from elastance ratio may indicate the highest level of lung stress in nondependent "baby" lung, where it is vulnerable to ventilator-induced lung injury.