American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Mar 2019
Near-Apneic Ventilation Decreases Lung Injury and Fibroproliferation in an ARDS Model with ECMO.
There is wide variability in mechanical ventilation settings during extracorporeal membrane oxygenation (ECMO) in patients with acute respiratory distress syndrome. Although lung rest is recommended to prevent further injury, there is no evidence to support it. ⋯ In an acute respiratory distress syndrome model supported with ECMO, near-apneic ventilation decreased histologic lung injury and matrix metalloproteinase activity, and prevented the expression of myofibroblast markers.
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Am. J. Respir. Crit. Care Med. · Mar 2019
Letter Randomized Controlled TrialLow-Dose Budesonide/Formoterol Counteracts Airway Inflammation and Improves Lung Function in COPD.
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Am. J. Respir. Crit. Care Med. · Mar 2019
Increased IgA Expression in Lung Lymphoid Follicles in Severe COPD.
Accumulation of B cells and lymphoid follicles (LFs) has been described in chronic obstructive pulmonary disease (COPD) airways, but the functional status of lung B cells remains poorly known. ⋯ This study shows that IgA production occurs in peribronchiolar LFs from severe COPD, where IL-21-producing T cells are present, and presumably represents a feature of exacerbated mucosal adaptive immune responses against microbial and/or self-antigens.