American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Jul 2020
A Network of Sputum MicroRNAs is Associated with Neutrophilic Airway Inflammation in Asthma.
Rationale: MicroRNAs are potent regulators of biologic systems that are critical to tissue homeostasis. Individual microRNAs have been identified in airway samples. However, a systems analysis of the microRNA-mRNA networks present in the sputum that contribute to airway inflammation in asthma has not been published. ⋯ Multiple microRNAs in the nely module correlated with two mRNA modules enriched for TLR (Toll-like receptor) and T-helper cell type 17 (Th17) signaling and endoplasmic reticulum stress. hsa-miR-223-3p was a key regulator of the TLR and Th17 pathways in the sputum of subjects with asthma. Conclusions: This study of sputum microRNA and mRNA expression from patients with asthma demonstrates the existence of microRNA networks and genes that are associated with features of asthma severity. Among these, hsa-miR-223-3p, a neutrophil-derived microRNA, regulates TLR/Th17 signaling and endoplasmic reticulum stress.
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Am. J. Respir. Crit. Care Med. · Jul 2020
Letter Case ReportsCOVID-19 Associated Pulmonary Aspergillosis.