American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Sep 2020
Editorial CommentRewiring the Immune Response in COVID-19.
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Am. J. Respir. Crit. Care Med. · Sep 2020
Comment Randomized Controlled Trial Multicenter StudyRecommended Reading from Boston University School of Medicine Fellows.
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Am. J. Respir. Crit. Care Med. · Sep 2020
Characterization of the Inflammatory Response to Severe COVID-19 Illness.
Rationale: Coronavirus disease (COVID-19) is a global threat to health. Its inflammatory characteristics are incompletely understood. Objectives: To define the cytokine profile of COVID-19 and to identify evidence of immunometabolic alterations in those with severe illness. ⋯ Conclusions: The COVID-19 cytokinemia is distinct from that of other types of pneumonia, leading to organ failure and ICU need. Neutrophils undergo immunometabolic reprogramming in severe COVID-19 illness. Cytokine ratios may predict outcomes in this population.