American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Feb 2022
Observational StudyHome Dust Allergen Exposure is Associated with Outcomes Among Sensitized Individuals with COPD.
Rationale: Environmental exposures have been associated with adverse outcomes in chronic obstructive pulmonary disease (COPD). Approximately one-third of individuals with COPD have allergic sensitization, but it is unknown whether exposure to allergens in the home is associated with outcomes. Objectives: To determine the prevalence and associations of allergen sensitization with exposure to common indoor allergens with symptoms and exacerbation risk in COPD. ⋯ Associations appeared to be more pronounced among individuals with lower lung function. Conclusions: Allergen exposures are common in COPD and associated with adverse outcomes among those with concomitant allergen sensitization. This study establishes allergens as an important home exposure that potentially could be addressed with comprehensive home environmental modification strategies to improve COPD outcomes.
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Am. J. Respir. Crit. Care Med. · Feb 2022
Letter Randomized Controlled TrialRapid Phospholipid Turnover After Surfactant Nebulization in Severe COVID-19 Infection: A Randomized Clinical Trial.