American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Mar 2023
Randomized Controlled Trial Multicenter StudyCPAP Effect on Albuminuria Progression in Patients with Obstructive Sleep Apnea and Diabetic Kidney Disease. A Randomized Clinical Trial.
Rationale: Obstructive sleep apnea (OSA) is associated with impaired glycemic control and a higher risk of vascular complications, such as diabetic kidney disease (DKD). However, the effect of apnea-hypopnea suppression on DKD progression is unclear. Objectives: To assess the effect of continuous positive airway pressure (CPAP) on the urinary albumin-to-creatinine ratio (UACR) in patients with DKD and OSA. ⋯ Conclusions: In patients with OSA and DKD, the prescription of CPAP did not result in a statistically significant reduction in albuminuria. However, good adherence to CPAP treatment in addition to usual care may result in long-term albuminuria reduction compared with usual care alone. Clinical trial registered with www.clinicaltrials.gov (NCT02816762).