American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Sep 2023
Randomized Controlled Trial Multicenter StudyThiamine for Renal Protection in Septic Shock (TRPSS): A Randomized, Placebo-Controlled Trial.
Rationale: Kidney injury is common and associated with worse outcomes in patients with septic shock. Mitochondrial resuscitation with thiamine (vitamin B1) may attenuate septic kidney injury. Objectives: To assess whether thiamine supplementation attenuates kidney injury in septic shock. ⋯ Conclusions: In the TRPSS trial, there was no statistically significant difference in the primary outcome of change in creatinine over time. Patients who received thiamine had more ICU-free days, but there was no difference in other secondary outcomes. Clinical trial registered with www.clinicaltrials.gov (NCT03550794).