American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Oct 2024
Sex-specific Genetic Determinants of Right Ventricular Structure and Function.
While sex differences in right heart phenotypes have been observed, the molecular drivers remain unknown. ⋯ BMPR1A has emerged as a biologically plausible candidate gene for female-specific genetic determination of RV function, showing associations with cardiac performance under chronically increased afterload in female patients with PAH.