American journal of respiratory and critical care medicine
The most recent articles from:
Am. J. Respir. Crit. Care Med.
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Am. J. Respir. Crit. Care Med. · May 2024
Proteomic Biomarkers of Survival in Idiopathic Pulmonary Fibrosis.
Rationale: Idiopathic pulmonary fibrosis (IPF) causes progressive lung scarring and high mortality. Reliable and accurate prognostic biomarkers are urgently needed. Objectives: To identify and validate circulating protein biomarkers of IPF survival. ⋯ In decision curve analysis, a proteomic signature of TFS outperformed a similarly derived clinical prediction model. Conclusions: In the largest proteomic investigation of IPF outcomes performed to date, we identified and validated 140 protein biomarkers of TFS. These results shed important light on potential drivers of IPF progression.
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Am. J. Respir. Crit. Care Med. · May 2024
Editorial Comment LetterMapping the Proteomic Landscape of Radiological Lung Abnormalities.