American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Mar 2014
Meta AnalysisAir Pollution and Non-Malignant Respiratory Mortality in 16 Cohorts within the ESCAPE Project.
Prospective cohort studies have shown that chronic exposure to particulate matter and traffic-related air pollution is associated with reduced survival. However, the effects on nonmalignant respiratory mortality are less studied, and the data reported are less consistent. ⋯ In this study of 16 cohorts, there was no association between air pollution exposure and nonmalignant respiratory mortality.
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Am. J. Respir. Crit. Care Med. · Oct 2012
Meta AnalysisGenome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.
Genome-wide association studies (GWAS) have identified loci influencing lung function, but fewer genes influencing chronic obstructive pulmonary disease (COPD) are known. ⋯ These results suggest an important role for the CHRNA5/3 region as a genetic risk factor for airflow obstruction that may be independent of smoking and implicate the HTR4 gene in the etiology of airflow obstruction.
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Am. J. Respir. Crit. Care Med. · Oct 2011
Multicenter Study Meta AnalysisOzone and survival in four cohorts with potentially predisposing diseases.
Time series studies have reported associations between ozone and daily deaths. Only one cohort study has reported the effect of long-term exposures on deaths, and little is known about effects of chronic ozone exposure on survival in susceptible populations. ⋯ This is the first study that follows persons with specific chronic conditions, and shows that long-term ozone exposure is associated with increased risk of death in these groups.
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Am. J. Respir. Crit. Care Med. · Nov 2010
Review Meta AnalysisAn official American Thoracic Society systematic review: insurance status and disparities in lung cancer practices and outcomes.
Insurance coverage is an important determinant of access to care and is one potential cause of disparities in lung cancer care outcomes. ⋯ Patients with Medicaid or no insurance consistently had worse outcomes than other patients with lung cancer. Some of the disparities may be secondary to residual confounding from smoking and other health behaviors, but available data suggest that patients with lung cancer without insurance do poorly because access to care is limited and/or they present with more advanced disease that is less amenable to treatment.
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Am. J. Respir. Crit. Care Med. · Oct 2009
Review Meta AnalysisMeta-analyses on suspected chronic obstructive pulmonary disease genes: a summary of 20 years' research.
Chronic obstructive pulmonary disease (COPD) is a complex disorder with high mortality worldwide. Studies on the role of candidate genes and their polymorphisms in COPD development have so far produced ambiguous results. ⋯ These results demonstrate the importance of ethnicity in identifying specific COPD genes.