Acta cardiologica
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Randomized Controlled Trial Comparative Study
Comparison of the effects of desflurane and sevoflurane on the QTc interval and QT dispersion.
The effects of desflurane and sevoflurane on QT interval and QT dispersion have been investigated in a prospective, double-blind, randomized study of patients undergoing noncardiac surgery. ⋯ The QTc interval was more prolonged with desflurane than sevoflurane, and QT dispersion was normal with both agents.
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Randomized Controlled Trial Comparative Study Clinical Trial
The effects of halothane and sevoflurane on QT dispersion.
QT dispersion is defined as the difference between QT (max) and QT (min) in the 12-lead surface ECG. It has been shown to reflect regional variations in ventricular repolarization and is significantly greater in patients with arrhythmic events than in those without them. The aim of this study was to examine the effects of halothane and sevoflurane on QT and QTc dispersion during inhalational induction of anaesthesia. ⋯ The QTc interval did not change by both sevoflurane (443 +/- 7 vs. 431 +/- 21 ms, P > 0.05) and halothane (419 +/- 33 vs. 431 +/- 19 ms, P > 0.05) compared with baseline. Both halothane and sevoflurane cause myocardial repolarisation abnormalities in man in terms of increased QTc dispersion. This may be relevant in the aetiology of arrhythmias in patients during anaesthesia with halothane or sevoflurane.
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Randomized Controlled Trial Comparative Study Clinical Trial Controlled Clinical Trial
Intravenous administration of diltiazem in the treatment of supraventricular tachyarrhythmias.
The aim of the study was to investigate the efficacy of diltiazem bolus intravenous administration, compared to disopyramide, in the treatment of various types of paroxysmal supraventricular tachyarrhythmias. ⋯ Diltiazem administration is extremely effective in conversion of paroxysmal atrial tachycardia to sinus rhythm. In addition it retards ventricular response in patients with atrial fibrillation and fluttering. Compared to disopyramide these effects of diltiazem are more pronounced and clinically pertinent.