Croatian medical journal
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Croatian medical journal · Apr 2024
The effect of somatic mutations in mitochondrial DNA on the survival of patients with primary brain tumors.
To assess the presence of mitochondrial (mt) DNA somatic mutations, determine the relationship between clinicopathological characteristics and mutations, and assess the survival outcomes in Malay patients with primary brain tumors. ⋯ mtDNA mutations negatively affected the survival outcomes of Malaysian patients with primary brain tumors. However, studies with larger samples are needed to confirm the association between mutation burden and survival rates.
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Croatian medical journal · Apr 2024
Screening for diabetic peripheral neuropathy at community pharmacies in Slovakia.
To identify diabetic patients with a potential risk of developing diabetic peripheral neuropathy (DPN) in community pharmacies in Slovakia using a modified Michigan Neuropathy Screening Instrument questionnaire (MNSIq-12). ⋯ The risk of developing DPN was detected in 6.6% of respondents with type 1 diabetes and 13.4% with type 2 diabetes. Patients with both types of diabetes (38.2%; 67.0%) reported fatigue and heaviness in the legs as the most common clinical symptoms that may indicate the development of DPN. Those with a Michigan score <1.5 were older (P<0.0001), had a higher BMI (P<0.0001), a lower level of education (P=0.0020), and were less physically active (P<0.0001). Conclusion Approximately one-eighth of patients with diabetes who visited community pharmacies were potentially at risk for developing DPN. The modified MNSIq-12 was shown to be a simple, time-effective, and non-invasive indicative screening tool that can be applied in the environment of community pharmacies.
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Croatian medical journal · Apr 2024
Factors contributing to variability in metformin concentration in polycystic ovary syndrome.
To investigate the factors affecting metformin concentrations after chronic administration in patients with polycystic ovary syndrome (PCOS), focusing on the pharmacokinetic variability and its implications for personalized therapy. ⋯ This study highlights the critical role of BMI in influencing metformin pharmacokinetics in PCOS patients and underscores the need for personalized treatment strategies in patients with PCOS.
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Croatian medical journal · Apr 2024
Exploring ChatGPT's abilities in medical article writing and peer review.
To evaluate the quality of ChatGPT-generated case reports and assess the ability of ChatGPT to peer review medical articles. ⋯ While ChatGPT demonstrated proficiency in generating case reports, there were limitations in terms of consistency and accuracy, especially in referencing.