Medicina
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Although aspirin (acetylsalicylic acid) has become widely available without prescription, cases of self-poisoning due to overdose of salicylates are quite uncommon, with a low reported mortality. However, severe poisoning with these preparations is life threatening. ⋯ On the basis of clinical and metabolic features or salicylate concentration in plasma it is very important to diagnose severe poisoning with salicylates in time and prescribe an adequate treatment. In the present review article various aspects of salicylate poisoning and its treatment are discussed: epidemiology, pharmacokinetics and pharmacodynamics of salicylates, clinical manifestations of their toxicity, management, enhanced elimination and prognosis.
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There are still many discussions among physicians how heart failure should be defined. Despite many suggested traditional classifications, majority of definitions circulating in clinical practice and their appropriate usage remain unclear. ⋯ Diagnostic strategy of acute heart failure as well as recommendations for prehospital and inpatient treatment of its forms (pulmonary edema and cardiogenic shock) are presented in the article. Application of new medications, recently introduced to the clinical practice for treatment of acute heart failure, is discussed.
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Comparative Study
Changes in serum electrolyte levels and their influence on the incidence of atrial fibrillation after coronary artery bypass grafting surgery.
Our study was designed to assess the incidence of atrial fibrillation, changes of serum electrolyte concentrations following coronary artery bypass grafting surgery. ⋯ 1. The incidence of atrial fibrillation after coronary artery bypass surgery remains relatively high (26.83%). 2. Serum electrolyte concentration after coronary artery bypass grafting varies within normal ranges. 3. Patients with postoperative atrial fibrillation had higher chloride and lower phosphate concentration immediately after surgery and lower ionized calcium and phosphate level 18-20 hours after the surgery.
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To evaluate initial (prehospital) assessment and management of high-energy blunt polytrauma patients. ⋯ Initial assessment of high-energy blunt polytrauma patients reached 14% and management reached 10.6% of that recommended by Advanced Trauma Life Support.
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Comparative Study
Effects of parathyroid hormone on newly regenerated bone during distraction osteogenesis in a rabbit tibial lengthening model. A pilot study.
The overall purpose of the study is to determine the effects of parathyroid hormone (PTH) (1-34) on bone formation in regenerated and surrounding bone of distracted callus during limb lengthening in rabbits. Additionally the aim of the pilot study is to titrate the optimal dose of PTH for distraction osteogenesis treatment in rabbits' tibial lengthening model. ⋯ PTH (1-34) treatment improved mineralization, structural indices of regenerated distracted rabbits' tibiae, whereas treatment at a dose of 25 microg/kg/day PTH (1-34) was significantly more effective than 5 microg/kg/day PTH(1-34) dose treatment when compared to control group. Bigger dose has been chosen for the main study.