Arthritis and rheumatism
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Arthritis and rheumatism · Dec 2001
Randomized Controlled Trial Clinical TrialEffect of a randomized, controlled trial of exercise on mood and physical function in individuals with fibromyalgia.
To evaluate the effect of exercise on mood and physical function in individuals with fibromyalgia. ⋯ Exercise can improve the mood and physical function of individuals with fibromyalgia.
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Arthritis and rheumatism · Nov 2001
Randomized Controlled Trial Multicenter Study Clinical TrialEffects of a ginger extract on knee pain in patients with osteoarthritis.
To evaluate the efficacy and safety of a standardized and highly concentrated extract of 2 ginger species, Zingiber officinale and Alpinia galanga (EV.EXT 77), in patients with osteoarthritis (OA) of the knee. ⋯ A highly purified and standardized ginger extract had a statistically significant effect on reducing symptoms of OA of the knee. This effect was moderate. There was a good safety profile, with mostly mild GI adverse events in the ginger extract group.
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Arthritis and rheumatism · Nov 2001
Randomized Controlled Trial Multicenter Study Clinical TrialEvaluation of the structure-modifying effects of diacerein in hip osteoarthritis: ECHODIAH, a three-year, placebo-controlled trial. Evaluation of the Chondromodulating Effect of Diacerein in OA of the Hip.
To evaluate the ability of diacerein, an interleukin-1beta inhibitor, to slow the progressive decrease in joint space width observed in patients with hip osteoarthritis (OA). ⋯ This study confirms previous clinical findings indicating that the demonstration of a structure-modifying effect in hip OA is feasible, and shows, for the first time, that treatment with diacerein for 3 years has a significant structure-modifying effect as compared with placebo, coupled with a good safety profile. The clinical relevance of these findings requires further investigation.
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Arthritis and rheumatism · Jul 2001
Randomized Controlled Trial Comparative Study Clinical TrialA randomized, double-blind, crossover clinical trial of diclofenac plus misoprostol versus acetaminophen in patients with osteoarthritis of the hip or knee.
To perform a randomized, double-blind, crossover clinical trial of diclofenac + misoprostol versus acetaminophen in ambulatory patients with osteoarthritis of the hip or knee. ⋯ Patients with osteoarthritis of the hip or knee had significantly greater improvements in pain scores over 6 weeks with diclofenac + misoprostol than with acetaminophen, although patients with mild osteoarthritis had similar improvements with both drugs. Acetaminophen was associated with fewer adverse events.
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Arthritis and rheumatism · Jul 2001
Randomized Controlled Trial Multicenter Study Clinical TrialStratification of flare intensity identifies placebo responders in a treatment efficacy trial of patients with osteoarthritis.
Studies evaluating osteoarthritis treatment often use increased arthritis activity ("flare") as a selection criterion, although no standardized assessments are available to quantify flare intensity and little is known about how this criterion affects treatment comparisons. This study evaluated the reliability of a flare assessment and how pretreatment flare intensity impacts conclusions on treatment efficacy. ⋯ Patients with higher intensity flares may be more likely to report substantial improvement in functional status regardless of treatment. Failure to account for flare intensity in analyses of data from pain trials with flare-based designs may inflate the risk of Type I and Type II errors in the interpretation of study results.