Arthritis and rheumatism
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Arthritis and rheumatism · Mar 2010
Randomized Controlled TrialTwo-year clinical and radiographic results with combination etanercept-methotrexate therapy versus monotherapy in early rheumatoid arthritis: a two-year, double-blind, randomized study.
To evaluate how continuation of and alterations to initial year 1 combination etanercept-methotrexate (MTX) therapy and MTX monotherapy regimens affect long-term remission and radiographic progression in early, active rheumatoid arthritis. ⋯ Early sustained combination etanercept-MTX therapy was consistently superior to MTX monotherapy. Combination therapy resulted in important clinical and radiographic benefits over 2 study years, without significant additional safety risk.
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Arthritis and rheumatism · Jan 2010
Randomized Controlled Trial Multicenter StudyEvaluation of the efficacy and safety of terguride in patients with fibromyalgia syndrome: results of a twelve-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study.
To assess the efficacy and safety of terguride, a partial dopamine agonist, in patients with fibromyalgia syndrome (FMS). ⋯ Terguride treatment did not improve pain, the FIQ score, the TPS, or the HDS score in the total study population. However, a subgroup of patients with cervical spine stenosis seemed to benefit from terguride treatment.
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Arthritis and rheumatism · Dec 2009
Randomized Controlled TrialA patient's perspective on multidisciplinary treatment gain for fibromyalgia: an indicator for pre-post treatment effects?
Increasing attention is devoted to the patient's perspective in clinical research and practice. However, the relationship between the patient's view on treatment progress and standardized pre-post changes in health outcomes is not well understood. The objective of this study was to investigate whether the patient's perception of treatment gain converges with pre-post treatment effects of a multidisciplinary treatment as assessed by standardized self-report measures. ⋯ Results suggest that the patient's perception of treatment gain and pre-post changes in outcomes during treatment assess different aspects of the patient's treatment progress, particularly with regard to psychological functioning. Future research on clinical improvements should consider the patient's perception of treatment gain as an independent and clinically relevant outcome, in addition to standardized trial data of pre-post assessments of health outcomes.
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Arthritis and rheumatism · Nov 2009
Randomized Controlled TrialTai Chi is effective in treating knee osteoarthritis: a randomized controlled trial.
To evaluate the effectiveness of Tai Chi in the treatment of knee osteoarthritis (OA) symptoms. ⋯ Tai Chi reduces pain and improves physical function, self-efficacy, depression, and health-related quality of life for knee OA.
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Arthritis and rheumatism · Nov 2009
Randomized Controlled TrialFunctional and work outcomes improve in patients with rheumatoid arthritis who receive targeted, comprehensive occupational therapy.
Work disability is a serious consequence of rheumatoid arthritis (RA). We conducted a 6-month, prospective randomized controlled trial comparing assessments of function, work, coping, and disease activity in employed patients with RA receiving occupational therapy intervention versus usual care. ⋯ Targeted, comprehensive occupational therapy intervention improves functional and work-related outcomes in employed RA patients at risk of work disability.