Journal of the American College of Surgeons
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Burn patients can incur high rates of hospital-acquired infections. The mechanism of antibiotic exposure on inducing infection vulnerability has not been determined. This study aimed to examine the effects of antibiotic treatment on host defense mechanisms. ⋯ Taken together with the fact that dead bacteria reversed antibiotic-induced K pneumoniae translocation and intestinal and pulmonary defense impairment, we conclude that combined antibiotic treatment results in systemic host defense impairment in burns through the decrease in intestinal flora. We suggest that dead bacteria supplementation could induce nondefensin protein expression and reverse antibiotic-induced gut and lung defense impairment in burn patients.
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Multicenter Study Comparative Study
A health system-based critical care program with a novel tele-ICU: implementation, cost, and structure details.
Improving the efficiency of critical care service is needed as the shortfall of intensivists is increasing. Standardizing clinical practice, telemedicine, and organizing critical care service at a health system level improves outcomes. We developed a health system Critical Care Program based at an academic medical center. The main feature of our program is an intensivist who shares on-site and telemedicine clinical responsibilities. Tele-ICU facilitates the standardization of high-quality critical care across the system. A common electronic medical record made the communications among the ICUs feasible. Combining faculty from medical and surgical critical care divisions increased the productivity of intensivists. ⋯ We describe a novel health system level ICU program built using "off the shelf" technology based on a large University medical center and a tele-ICU with a full degree of treatment authority across the system.
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Multicenter Study
Profiling hospitals on bariatric surgery quality: which outcomes are most reliable?
Under the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program, hospitals will receive risk-adjusted outcomes feedback for peer comparisons and benchmarking. It remains uncertain whether bariatric outcomes have adequate reliability to identify outlying performance, especially for hospitals with low caseloads that will be included in the program. We explored the ability of risk-adjusted outcomes to identify outlying hospital performance with bariatric surgery for a range of hospital caseloads. ⋯ Overall complications and serious complications have adequate reliability for distinguishing outlying performance with bariatric surgery, even for hospitals with low annual caseloads. Rare outcomes, such as reoperations, have inadequate reliability to inform peer-based comparisons for hospitals with low annual caseloads, and mortality has unacceptably low reliability for bariatric performance profiling.
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Multicenter Study
Entrustment of general surgery residents in the operating room: factors contributing to provision of resident autonomy.
Several challenges threaten the traditional premise of graduated independence in general surgery training, leading to a lack of readiness in graduating surgeons. The objective of this study was to determine the factors contributing to faculty decisions to grant residents autonomy in the operating room, the barriers to granting this autonomy, and the factors that facilitate entrustment. ⋯ This study identified several factors that attending surgeons report as significant limitations to transitioning autonomy to surgical residents in the operating room. These issues must be addressed in a direct manner if progressive graduated responsibility to independence is to occur in the next era of graduate surgical training.