Journal of the American College of Surgeons
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Immunotherapy has achieved effective antitumor activity in advanced GC patients. However, the rate of response to ICI therapy is disappointing, T cell exhaustion may contribute to this phenomenon. EBI3 is an emerging immunosuppressive factor, and the association between EBI3 and T cell exhaustion is not clear. In this study, we aimed to explore the expression of EBI3 in GC, and reveal the function of EBI3 in T cell exhaustion. ⋯ Our study indicated that EBI3 is an important cytokine in the development of GC, and EBI3 may promote the development of GC by inducing T cell exhaustion in the tumor microenvironment.
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Hemipelvectomy is a complex surgery that is usually performed with curative intent. It is rarely performed for palliation in patients with advanced cancer, and its efficacy in achieving palliation is unknown. ⋯ Palliative-intent hemipelvectomy provided palliation in a minority of patients, did not improve function, and had high morbidity and mortality. Patients with small anterior pelvic tumors may benefit from palliative hemipelvectomy; for others, less invasive approaches should be considered whenever feasible.