Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
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Meta Analysis Comparative Study
A meta-analysis of cervical arthroplasty compared to anterior cervical discectomy and fusion for single-level cervical disc disease.
There is no consensus on whether anterior cervical arthroplasty or anterior cervical discectomy and fusion (ACDF) is the optimal treatment for single-level cervical radiculopathy or myelopathy. We conducted a meta-analysis of randomized controlled trials to compare the safety and efficacy of anterior cervical arthroplasty with ACDF. ⋯ However, there were no significant differences in the neck disability index (NDI) scores (MD=-3.81, 95% CI=-8.12 to 0.51), number of adverse events (RR=0.77, 95% CI=0.48 to 1.23), or radiological success rate (OR=0.87, 95% CI=0.36 to 2.09). Based on this meta-analysis, cervical arthroplasty is a safe and effective surgical procedure for treating single-level cervical radiculopathy or myelopathy.
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A meta-analysis was conducted to assess the safety and efficacy of balloon kyphoplasty (KP) compared to percutaneous vertebroplasty (VP) in the treatment of osteoporotic vertebral compression fractures (OVCF). Ten studies, encompassing 783 patients, met the inclusion criteria. Overall, the results of the meta-analysis indicated that there were significant differences between the two groups in the long-term kyphosis angle (mean difference [MD] = -2.64, 95% confidence interval [CI] = -4.66 to -0.61; p = 0.01), the anterior height of the vertebral body (MD = 3.67, 95% CI = 1.40 to 5.94; p = 0.002), and the cement leakage rates (risk ratio [RR] = 0.70, 95% CI = 0.52 to 0.95; p = 0.02). ⋯ This meta-analysis demonstrates that KP and VP are both safe and effective surgical procedures for treating OVCF. Compared with VP, KP can significantly relieve a long-term kyphosis angle, improve the height of the vertebral body, and reduce the incidence of bone cement leakage. However, because of the limitations of this meta-analysis, a large randomized controlled trial is required to confirm our findings.
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We used PubMed, Medline, and EMBASE to conduct a meta-analysis to determine the significance of high signal intensity on T2-weighted MRI for predicting postoperative prognosis in patients with cervical spondylotic myelopathy (CSM). Although patients with CSM with high signal intensity on T2-weighted MRI usually had a poor prognosis even after undergoing surgery, some researchers have argued recently that high-intensity signals are not associated with postoperative prognosis. Data consistent with the inclusion criteria of this study were cited for meta-analysis using Review Manager 5 Software. ⋯ Five articles (one prospective; four retrospective) involving 309 patients with CSM were included. The aggregate WMD with regard to the postoperative JOA recovery ratio between the T2-weighted high signal intensity positive (+) group and the T2-weighted high signal intensity negative (-) group was -6.56, and the 95% confidence interval (CI) was -12.15 to -0.97 (p=0.02). Thus, we concluded that in patients with CSM, the postoperative JOA recovery ratio in the T2-weighted (+) group was lower than that in the T2-weighted (-) group.
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Meta Analysis Comparative Study
Hearing preservation rates after microsurgical resection of vestibular schwannoma.
Preservation of hearing is a major goal of surgery for patients with vestibular schwannoma (VS). We performed an analysis of the published literature on hearing outcome after microsurgery for VS. Our objective was to provide a comprehensive and unbiased description of published results. ⋯ Patients undergoing surgery via the MCF had better hearing outcomes on univariate analysis than those undergoing the RS approach (63% vs. 47%, p<0.0001). Multivariate analysis found that tumor size >1.5cm (odds ratio [OR] 2.81, 95% confidence interval [CI]=1.59-4.95, p<0.001), and the RS approach (OR 4.15, 95% CI=1.97-8.77, p<0.001) were independent significant risk factors for loss of serviceable hearing during VS surgery. Use of the MCF demonstrates superior hearing outcomes to the RS approach, even after correcting for the effect of the increased size of tumors addressed by the RS approach.
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Review Meta Analysis
A meta analysis of treating subarachnoid hemorrhage with magnesium sulfate.
Despite the publication of several randomized controlled studies, there is still much debate on whether magnesium sulfate improves outcome in patients with aneurysmal subarachnoid hemorrhage. Here we present data to assess the clinical effectiveness of magnesium sulfate in the prevention of cerebral vasospasm in patients who have suffered from aneurysmal subarachnoid hemorrhage. The EMBASE and PubMed databases were searched using the following terms: "magnesium sulfate" or "MgSO(4)" with "subarachnoid hemorrhage" or "cerebral vasospasm". ⋯ The occurrence of poor outcome (death, vegetative state, or dependency) in patients treated with magnesium sulfate was less likely than control group patients (odds ratio [OR] 0.54 [95% confidence interval, CI 0.36-0.81]). Mortality rates did not differ between magnesium sulfate (14%) and control treated (12%) patients (OR 1.16 [95% CI 0.51-2.65]). Our results indicate that although there was reduced likelihood of a poor outcome for patients treated with magnesium sulfate after SAH, patient mortality was not improved.