Journal of investigative medicine : the official publication of the American Federation for Clinical Research
-
We assessed the effect of a cytokine inhibitor, compound SKF 86002 (a bicyclic imidazole), on changes in renal hemodynamics (renal blood flow and glomerular filtration rate) that occur acutely following immune injury of glomerular mesangial cells. ⋯ The observations indicate that in mesangial cell immune injury, cytokines mediate renal hemodynamic impairment.
-
Comparative Study
Effects of Carbicarb and sodium bicarbonate on hypoxic lactic acidosis in newborn pigs.
Use of sodium bicarbonate (NaHCO3) may result in intracellular acidosis due to the generation of CO2. Carbicarb, has been reported to be superior to sodium bicarbonate (NaHCO3) because of lesser generation of CO2. The present study was designed to investigate whether Carbicarb or NaHCO3 is superior to normal saline in the treatment of hypoxic lactic acidosis. ⋯ The data demonstrate that 1) both Carbicarb and NaHCO3 significantly increase arterial pCO2; and 2) use of either alkalinizing agent in moderate acidosis does not alter the course of acidosis.