Archives of disease in childhood. Fetal and neonatal edition
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Arch. Dis. Child. Fetal Neonatal Ed. · Mar 1998
Randomized Controlled Trial Clinical TrialRandomised controlled trial of eutectic mixture of local anaesthetics cream for venepuncture in healthy preterm infants.
To assess the safety and efficacy of EMLA cream (eutectic mixture of local anaesthetics) used to induce surface anaesthesia for venepuncture in healthy preterm infants. ⋯ This study does not support the routine use of EMLA for venepuncture in healthy preterm infants.
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Arch. Dis. Child. Fetal Neonatal Ed. · Nov 1997
Randomized Controlled Trial Comparative Study Clinical TrialRandomised trial of volume controlled versus time cycled, pressure limited ventilation in preterm infants with respiratory distress syndrome.
Fifty preterm infants weighing 1200 g or more with clinical and radiographic evidence of respiratory distress syndrome, requiring both mechanical ventilation and exogenous surfactant replacement, were randomly allocated to receive either volume controlled ventilation or time cycled, pressure limited ventilation. Tidal volume delivery in each group was deliberately controlled at 5-8 ml/kg so that the only difference between the two groups was the ventilatory modality, the manner in which tidal volume was delivered. The rest of the ventilatory management and clinical care was done according to protocol. ⋯ Infants randomised to volume controlled ventilation met success criteria sooner and had a shorter duration of mechanical ventilation. These babies also had a significantly lower incidence of intraventricular haemorrhages and abnormal periventricular echodensities on ultrasound scans. Volume controlled ventilation seems to be both safe and effective in this group of patients.
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Arch. Dis. Child. Fetal Neonatal Ed. · Sep 1997
Randomized Controlled Trial Clinical TrialCisapride reduces neonatal postoperative ileus: randomised placebo controlled trial.
To assess the efficacy of cisapride in reducing ileus persisting to the tenth postoperative day after neonatal abdominal surgery. ⋯ Cisapride is effective in neonates with a prolonged ileus after abdominal surgery.
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Arch. Dis. Child. Fetal Neonatal Ed. · Sep 1997
Randomized Controlled Trial Comparative Study Clinical TrialRandomised controlled trial: comparison of colloid or crystalloid for partial exchange transfusion for treatment of neonatal polycythaemia.
To compare the efficacy of using isotonic saline (crystalloid) or 5% albumin (colloid) as replacement fluid in partial exchange transfusion (PET) for the treatment of neonatal polycythaemia. ⋯ Both isotonic saline and 5% albumin are effective when used as replacement fluid in PET for the treatment of neonatal polycythaemia. Isotonic saline, which is cheaper and free of infection, should be the replacement fluid of choice.
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Arch. Dis. Child. Fetal Neonatal Ed. · Jul 1997
Randomized Controlled Trial Comparative Study Clinical TrialPulmonary function changes after nebulised and intravenous frusemide in ventilated premature infants.
To compare the effects of a single dose of frusemide administered either intravenously or by nebulisation on pulmonary mechanics in premature infants with evolving chronic lung disease. ⋯ Single dose nebulised frusemide improves pulmonary function in premature infants with evolving chronic lung disease without adverse effects on fluid and electrolyte balance.