Current opinion in critical care
-
Curr Opin Crit Care · Feb 2014
ReviewSpontaneous breathing in mild and moderate versus severe acute respiratory distress syndrome.
This review summarizes the most recent clinical and experimental data on the impact of spontaneous breathing in acute respiratory distress syndrome (ARDS). ⋯ Clinical and experimental studies show that controlled mechanical ventilation with muscle paralysis in the early phase of severe ARDS reduces lung injury and even mortality. At present, spontaneous breathing should be avoided in the early phase of severe ARDS, but considered in mild-to-moderate ARDS.
-
Curr Opin Crit Care · Feb 2014
ReviewHigh-frequency oscillatory ventilation for early acute respiratory distress syndrome in adults.
High-frequency oscillatory ventilation (HFOV) has been considered a potentially ideal mode of lung-protective ventilation. A recent meta-analysis suggested improved oxygenation and reduced mortality in adults and children with acute respiratory distress syndrome (ARDS), but the use of outdated control strategies and small numbers of patients in many of the studies rendered these findings hypothesis-generating only. ⋯ The OSCILLATE and OSCAR trials showed that the early application of HFOV in moderate-to-severe adult ARDS does not reduce mortality compared with conventional ventilation strategies. Future studies on HFOV will need to identify those patients who might benefit most from HFOV and to determine the best oscillator settings. Both goals require an improved capability of monitoring recruitment and overdistension, and oscillatory volumes.
-
Esophageal pressure measurement well estimates pleural pressure. The interpretation of absolute values is often debated for various reasons, but the changes in pressure measured are considered very accurate provided that a number of precautions are taken. The information provided by these measurements is unique in nature and has an enormous potential to influence management. It allows to study the exact influence of the chest wall and to determine the real lung distending pressure. It is also the only way to quantify respiratory muscle activity and the work of breathing. ⋯ Application of esophageal pressure monitoring is limited by technical issues, the need for background physiological knowledge and the fact that very few studies have assessed a direct influence of this measurement on patients' outcome. The technique is underused in everyday practice.
-
Curr Opin Crit Care · Feb 2014
ReviewCell-based therapies for the acute respiratory distress syndrome.
Acute respiratory distress syndrome (ARDS) is a multifaceted lung disease with no current effective therapy. Many clinical trials using conventional pharmacologic therapies have failed, suggesting the need to examine alternative approaches. Thus, attention has focused on the therapeutic potential of cell-based therapies for ARDS, with promising results demonstrated in relevant preclinical disease models. We review data concerning the therapeutic promise of cell-based therapies for ARDS. ⋯ Cell-based therapies offer considerable promise for the treatment of ARDS. While MSC-based therapies are being rapidly advanced toward clinical testing, clear therapeutic potential exists for other cell types for ARDS. A greater understanding of current knowledge gaps should further enhance the therapeutic potential of cell-based therapies for ARDS.
-
Curr Opin Crit Care · Feb 2014
ReviewWhat is the future of acute respiratory distress syndrome after the Berlin definition?
To analyze recently published articles in the medical literature that studied distinct aspects of adult patients with acute respiratory distress syndrome (ARDS) after the new Berlin definition introduced in 2012. ⋯ The impact of the Berlin definition of ARDS on the incidence, better treatment stratification and mortality ratio of ARDS is still to be determined.