Current opinion in critical care
The most recent articles from:
Curr Opin Crit Care
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Curr Opin Crit Care · Oct 2023
ReviewOptimal drug therapy for Staphylococcus aureus bacteraemia in adults.
Staphylococcus aureus is a significant human pathogen, causing a variety of infections, from skin and soft tissue infections to endocarditis, bone and joint infections and deep tissue abscesses. Mortality from S. aureus bacteraemia remains high, without major therapeutic advances in recent decades. ⋯ This review details the different PK/PD targets for drugs used to treat S. aureus bacteraemia and how to apply them in various scenarios. The drug doses that achieve them, and the risks of toxicity are also provided.