Current opinion in critical care
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Curr Opin Crit Care · Apr 2002
ReviewTherapeutic approaches to vasospasm in subarachnoid hemorrhage.
Delayed vasospasm as a result of subarachnoid blood after rupture of a cerebral aneurysm is a major complication. It is seen in over half of patients and causes symptomatic ischemia in about one third. ⋯ The mainstays of treatment are careful maintenance of fluid balance, induced hypervolemia and hypertension, calcium antagonists, balloon or chemical angioplasty, and, in some centers, cisternal fibrinolytic drugs. Promising future lines of treatment include gene therapy, nitric oxide donors, magnesium, sustained release cisternal drugs, and several other drugs that are under experimental or clinical trial.
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Curr Opin Crit Care · Apr 2002
ReviewAdvanced monitoring in the intensive care unit: brain tissue oxygen tension.
Cerebral monitoring of patients with acute intracranial disorders generally focuses on intracranial pressure and cerebral perfusion pressure monitoring. Over the past few years, several new techniques have become available for more detailed routine monitoring of cerebral oxygenation and metabolism. Brain tissue oxygen pressure measurement is increasingly being used for evaluation of cerebral oxygenation. ⋯ Published experimental and clinical data are considered, and the current status of the clinical use and indications of the technique are summarized. Monitoring may be performed in relatively undamaged parts of the brain or, preferably, in the penumbra region of an intracerebral lesion. Pathophysiologic evidence warrants targeting therapy for patients with traumatic brain injury and subarachnoid hemorrhage toward improvement of cerebral oxygenation guided by continuous monitoring of brain tissue oxygen tension.
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Curr Opin Crit Care · Apr 2002
ReviewAdvanced monitoring in the neurology intensive care unit: microdialysis.
Cerebral microdialysis is a relatively new technique for measuring the levels of brain extracellular chemicals, which to date has predominantly been used as a research tool. This review considers the technical aspects of microdialysis, the importance of the commonly measured chemicals, and the use of microdialysis to monitor patients with ischemic stroke, head injury, and subarachnoid hemorrhage. The advantages and disadvantages of microdialysis are discussed, as is its future potential.
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Ventilator-associated pneumonia usually originates from the patient's oropharyngeal microflora. In selective digestive decontamination, topical antibiotics are applied to the oropharynx and stomach for prevention of pneumonia and other infections, possibly reducing infection-related mortality. Selective digestive decontamination is also used for the prevention of gut-derived infections in acute necrotizing pancreatitis and liver transplantation. ⋯ Mortality was not reduced in most individual trials, but this finding was calculated in meta-analyses, especially for combined use of topical and systemic antibiotics in surgical ICU patients. Some investigators reported increased resistance and a shift to Gram-positive pathogens. Today, it appears that selective means not only selective suppression of pathogenic bacteria but also selection of appropriate groups of patients for underlying diseases and severity of illness, and selection of ICUs, where the endemic resistance patterns might allow the use of selective digestive decontamination at a relatively low risk for increased selection pressure.
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The unique pathophysiology of patients with end-stage liver disease has important implications for their critical care treatment, particularly in the postoperative state. To gauge hemodynamic parameters and responses, each patient must be carefully evaluated for their place in the clinical spectrum of cirrhosis and portal hypertension. Although the data are limited, the biology of the consequences of liver disease is emphasized by novel treatments of hepatorenal syndrome, portopulmonary hypertension, and hepatopulmonary syndrome. These issues become more relevant with increased adult-to-adult living donor liver transplantation, in which technical considerations may further complicate the general treatment of the postoperative transplant patient.