Multiple sclerosis : clinical and laboratory research
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Corrigendum to 25-hydroxyvitamin D in cerebrospinal fluid during relapse and remission of multiple sclerosis by Trygve Holmøy, Stine Marit Moen, Thomas A Gundersen, Michael F Holick, Enrico Fainardi, Massimiliano Castellazzi and Ilaria Casetta. 15(11) 1280-1285 [DOI: 10.1177/1352458509107008].
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Histopathological studies have revealed four different immunopathological patterns of lesion pathology in early multiple sclerosis (MS). Pattern II MS is characterised by immunoglobulin and complement deposition in addition to T-cell and macrophage infiltration and is more likely to respond to plasma exchange therapy, suggesting a contribution of autoantibodies. ⋯ This is the largest study on established anti-neural antibodies performed in MS so far. MOG-IgG may play a role in a small percentage of patients diagnosed with pattern II MS.
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Corrigendum to Ragheb, S et al. (2011). Multiple sclerosis: BAFF and CXCL13 in cerebrospinal fluid Multiple Sclerosis Journal 17(07) 819-829. [DOI: 10.1177/1352458511398887].
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Deep gray matter (DGM) atrophy is common in multiple sclerosis (MS), but no studies have investigated surface-based structure changes over time with respect to healthy controls (HCs). Moreover, the relationship between cognition and the spatio-temporal evolution of DGM atrophy is poorly understood. ⋯ These findings highlight the role of atrophy in the anterior nucleus of the thalamus and its relation to cognitive decline in MS.