Journal of cardiovascular pharmacology and therapeutics
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J. Cardiovasc. Pharmacol. Ther. · Jul 2013
Randomized Controlled TrialEffect of a single high loading dose of rosuvastatin on percutaneous coronary intervention for acute coronary syndromes.
A high loading dose of atorvastatin has been confirmed to reduce postprocedural events in patients undergoing percutaneous coronary intervention (PCI). In this study, we sought to investigate the protective effects of rosuvastatin in patients with acute coronary syndromes (ACS) undergoing PCI and to determine the effect of rosuvastatin pretreatment on the postprocedural levels of high-sensitivity C-reactive protein (hs-CRP), interleukin 6 (IL-6), and monocyte chemotactic protein 1 (MCP-1). ⋯ A single, high dose (20 mg) of rosuvastatin prior to PCI reduces postprocedural myocardial injury in patients with ACS, with a concomitant attenuation of the postprocedural increase in hs-CRP and IL-6 levels.
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J. Cardiovasc. Pharmacol. Ther. · Sep 2012
Randomized Controlled TrialEffect of prostaglandin E1 on pulmonary arterial hypertension following corrective surgery for congenital heart disease.
To evaluate the therapeutic effects of prostaglandin E(1) (PGE(1)) on residual pulmonary arterial hypertension (PAH) after corrective surgery for congenital heart disease. ⋯ Intravenous PGE(1) therapy after corrective surgery for congenital heart disease was associated with a reduction in mean pulmonary arterial pressure and a lower risk of death.
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J. Cardiovasc. Pharmacol. Ther. · Sep 2007
Randomized Controlled Trial Comparative StudyConversion of atrial fibrillation to sinus rhythm during treatment with intravenous esmolol or diltiazem: a prospective, randomized comparison.
Prior studies have suggested that intravenous diltiazem reduces the probability of spontaneous conversion of atrial fibrillation (AF) to sinus rhythm in the electrophysiology laboratory and in patients with postoperative AF. Whether diltiazem exerts the same effect in patients presenting to the emergency department (ED) with spontaneous AF is unclear. ⋯ Conversion to sinus rhythm occurred in 10 patients (42%) in the diltiazem group compared with 10 patients (39%) in the esmolol group (P = 1.0). Diltiazem does not decrease the likelihood of spontaneous conversion of AF to sinus rhythm in the ED setting.
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J. Cardiovasc. Pharmacol. Ther. · Mar 2003
Randomized Controlled Trial Comparative Study Clinical TrialLeft ventricular performance during acute rate control in atrial fibrillation: the importance of heart rate and agent used.
The relation between heart rate and left ventricular function during rate control in atrial fibrillation is incompletely understood. ⋯ In patients with acute atrial fibrillation, digoxin led to similar improvements in ejection fraction compared to diltiazem despite a slower and less potent heart rate slowing.