Drug discovery today
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Drug discovery today · Mar 2005
ReviewDiscovery and development of biomarkers of neurological disease.
The identification of clinically relevant biomarkers for neurological diseases poses unique challenges. These include an historical lack of availability of relevant tissues from the site of pathology, relatively poorly matured techniques for disease diagnosis, the complexity and cellular heterogeneity of the brain, and a clear deficiency of models for functional validation of candidate biomarkers. Here, the unique challenges that neurological disorders introduce to biomarker discovery are described and how modern technological advances in genomics, proteomics and metabolomics are overcoming these obstacles and are driving the discovery of novel biomarkers to improve early diagnosis and therapeutic treatment is discussed.
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Drug discovery today · Jan 2005
Chris Ashton talks about his career and the recent merger of Argenta Discovery and Etiologics. Interview by Steve Carney.
Chris Ashton describes the driving force behind the merger of Argenta Discovery and Etiologics, as well as detailing the highlights and strategies of the company's new drug discovery programme.