Annals of internal medicine
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Randomized Controlled Trial Clinical Trial
Prevention of exacerbations of chronic obstructive pulmonary disease with tiotropium, a once-daily inhaled anticholinergic bronchodilator: a randomized trial.
Patients with chronic obstructive pulmonary disease (COPD) frequently develop exacerbations, leading to major clinical and health resource use ramifications. ⋯ Tiotropium reduces COPD exacerbations and may reduce related health care utilization in patients with moderate to severe COPD.
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This statement summarizes the U. S. ⋯ The complete information on which this statement is based, including evidence tables and references, is included in the evidence synthesis available through the USPSTF Web site (http://www.preventiveservices.ahrq.gov). The recommendation is also posted on the Web site of the National Guideline Clearinghouse (http://www.guideline.gov).