Annals of internal medicine
-
New treatments are available for treatment of venous thromboembolism. ⋯ The strength of evidence varies across the study questions but generally is strong.
-
Randomized Controlled Trial
Diagnosis and initial management of obstructive sleep apnea without polysomnography: a randomized validation study.
Polysomnography (PSG), despite limited availability and high cost, is currently recommended for diagnosis of obstructive sleep apnea and titration of effective continuous positive airway pressure (CPAP). ⋯ In the initial management of patients with a high probability of obstructive sleep apnea, PSG confers no advantage over the ambulatory approach in terms of diagnosis and CPAP titration. The ambulatory approach may improve adherence to treatment. When access to PSG is inadequate, the ambulatory approach can be used to expedite management of patients most in need of treatment.