Annals of internal medicine
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Review Meta Analysis
C-reactive protein as a risk factor for coronary heart disease: a systematic review and meta-analyses for the U.S. Preventive Services Task Force.
C-reactive protein (CRP) may help to refine global risk assessment for coronary heart disease (CHD), particularly among persons who are at intermediate risk on the basis of traditional risk factors alone. ⋯ Strong evidence indicates that CRP is associated with CHD events. Moderate, consistent evidence suggests that adding CRP to risk prediction models among initially intermediate-risk persons improves risk stratification. However, sufficient evidence that reducing CRP levels prevents CHD events is lacking.
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Neuraminidase inhibitors (NAIs) are stockpiled internationally for extended use in an influenza pandemic. ⋯ Extended-duration zanamivir and oseltamivir chemoprophylaxis seems to be highly efficacious for preventing symptomatic influenza among immunocompetent white and Japanese adults. Extended-duration oseltamivir is associated with increased nausea and vomiting. Safety and efficacy in several subpopulations that might receive extended-duration influenza chemoprophylaxis are unknown.
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Randomized Controlled Trial
Facemasks and hand hygiene to prevent influenza transmission in households: a cluster randomized trial.
Few data are available about the effectiveness of nonpharmaceutical interventions for preventing influenza virus transmission. ⋯ Centers for Disease Control and Prevention.
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Recent proposals to reform primary care have encouraged physician practices to adopt such structural capabilities as performance feedback and electronic health records. Whether practices with these capabilities have higher performance on measures of primary care quality is unknown. ⋯ The Commonwealth Fund.