Annals of internal medicine
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Review Meta Analysis
Association between atrial fibrillation and silent cerebral infarctions: a systematic review and meta-analysis.
Atrial fibrillation (AF) is a common cause of stroke. Silent cerebral infarctions (SCIs) are known to occur in the presence and absence of AF, but the association between these disorders has not been well-defined. ⋯ Deane Institute for Integrative Research in Atrial Fibrillation and Stroke, Massachusetts General Hospital.
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Gout is the most common inflammatory arthritis in the United States. ⋯ Agency for Healthcare Research and Quality.
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The interferon (IFN)-free regimen of sofosbuvir and ribavirin for 24 weeks was recently approved to treat chronic hepatitis C virus (HCV) genotype 1 (GT-1) infection for patients ineligible for IFN. However, sofosbuvir plus ribavirin therapy is associated with relapse in 15% to 30% of patients with HCV GT-1. Neither the mechanism of relapse nor the optimal re-treatment strategy for these patients is defined. ⋯ National Institute of Allergy and Infectious Diseases, National Institutes of Health, National Cancer Institute, and Gilead Sciences.