Annals of internal medicine
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Review Meta Analysis Comparative Study
Biological agents for moderately to severely active ulcerative colitis: a systematic review and network meta-analysis.
Biological agents are emerging treatment options for the management of ulcerative colitis (UC). ⋯ Biological agents are effective treatments for UC, but head-to-head trials are warranted to establish the best therapeutic option.
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Comparative Study
Health and economic benefits of early vaccination and nonpharmaceutical interventions for a human influenza A (H7N9) pandemic: a modeling study.
Vaccination for the 2009 pandemic did not occur until late in the outbreak, which limited its benefits. Influenza A (H7N9) is causing increasing morbidity and mortality in China, and researchers have modified the A (H5N1) virus to transmit via aerosol, which again heightens concerns about pandemic influenza preparedness. ⋯ Agency for Healthcare Research and Quality, National Institutes of Health, and Department of Veterans Affairs.
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Childhood cancer survivors treated with anthracyclines are at high risk for asymptomatic left ventricular dysfunction (ALVD), subsequent heart failure, and death. The consensus-based Children's Oncology Group (COG) Long-Term Follow-up Guidelines recommend lifetime echocardiographic screening for ALVD. ⋯ The COG guidelines could reduce the risk for heart failure in survivors at less than $100 000/QALY. Less frequent screening achieves most of the benefits and would be more cost-effective than the COG guidelines.