Annals of internal medicine
-
Expert guidelines recommend reducing or discontinuing long-term opioid therapy (LTOT) when risks outweigh benefits, but evidence on the effect of dose reduction on patient outcomes has not been systematically reviewed. ⋯ Veterans Health Administration. (PROSPERO: CRD42015020347).
-
Review
Benefits and Risks of Antithrombotic Therapy in Essential Thrombocythemia: A Systematic Review.
Patients with essential thrombocythemia (ET) are at high risk for both thrombosis and hemorrhage. ⋯ Regional Medical Associates. (PROSPERO: CRD42015027051).
-
Osteoporosis is a common systemic skeletal disorder resulting in bone fragility and increased fracture risk. However, management of osteoporosis and fracture prevention strategies are often not addressed by primary care clinicians, even in older patients with recent fractures. Evidence-based screening strategies will improve identification of patients who are most likely to benefit from drug treatment to prevent fracture. In addition, careful consideration of when pharmacotherapy should be started and choice of medication and duration of treatment will maximize the benefits of fracture prevention while minimizing potential harms of long-term drug exposure.
-
Clostridium difficile infection (CDI), the most common health care-associated infection, often recurs. Fecal microbiota transplantation is increasingly used to treat multiply recurrent CDI (mrCDI). ⋯ National Institute of Diabetes and Digestive and Kidney Diseases and National Institute of Allergy and Infectious Diseases.