Annals of internal medicine
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Randomized Controlled Trial
The Impact of Whole-Genome Sequencing on the Primary Care and Outcomes of Healthy Adult Patients: A Pilot Randomized Trial.
Whole-genome sequencing (WGS) in asymptomatic adults might prevent disease but increase health care use without clinical value. ⋯ National Institutes of Health.
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Expert guidelines recommend reducing or discontinuing long-term opioid therapy (LTOT) when risks outweigh benefits, but evidence on the effect of dose reduction on patient outcomes has not been systematically reviewed. ⋯ Veterans Health Administration. (PROSPERO: CRD42015020347).
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Clostridium difficile infection (CDI), the most common health care-associated infection, often recurs. Fecal microbiota transplantation is increasingly used to treat multiply recurrent CDI (mrCDI). ⋯ National Institute of Diabetes and Digestive and Kidney Diseases and National Institute of Allergy and Infectious Diseases.