Annals of internal medicine

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• Ann. Intern. Med. · Apr 2021

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  In older adults without CVD, treating 100 persons with statins for 2.5 y prevents 1 MACE.

  Yourman LC, Cenzer IS, Boscardin WJ, et al. Evaluation of time to benefit of statins for the primary prevention of cardiovascular events in adults aged 50 to 75 years: a meta-analysis. JAMA Intern Med. 2021;181:179-85. 33196766.

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• Ann. Intern. Med. · Apr 2021

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  Joint testing of IgM and IgG has high value for ruling in SARS-CoV-2 infection.

  Guo CC, Mi JQ, Nie H. Seropositivity rate and diagnostic accuracy of serological tests in 2019-nCoV cases: a pooled analysis of individual studies. Eur Rev Med Pharmacol Sci. 2020;24:10208-18. 33090430.

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• Ann. Intern. Med. · Apr 2021

  Comment

  In patients with AF and a bioprosthetic mitral valve, rivaroxaban was noninferior to warfarin for time to clinical events.

  Guimarães HP, Lopes RD, de Barros E Silva PG, et al. Rivaroxaban in patients with atrial fibrillation and a bioprosthetic mitral valve. N Engl J Med. 2020;383:2117-26. 33196155.

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• Ann. Intern. Med. · Apr 2021

  Comment

  In imaging-selected ischemic stroke with unknown onset, alteplase increases favorable outcomes and death at 90 d.

  Thomalla G, Boutitie F, Ma H, et al. Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data. Lancet. 2020;396:1574-84. 33176180.

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• Ann. Intern. Med. · Apr 2021

  Comment

  In at-risk patients without CVD, polypill plus aspirin reduced a composite of major CV events at 4.6 y.

  Yusuf S, Joseph P, Dans A, et al. Polypill with or without aspirin in persons without cardiovascular disease. N Engl J Med. 2021;384:216-28. 33186492.

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