Annals of internal medicine
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Randomized Controlled Trial Observational Study
Temporal Improvements in COVID-19 Outcomes for Hospitalized Adults: A Post Hoc Observational Study of Remdesivir Group Participants in the Adaptive COVID-19 Treatment Trial.
The COVID-19 standard of care (SOC) evolved rapidly during 2020 and 2021, but its cumulative effect over time is unclear. ⋯ National Institute of Allergy and Infectious Diseases.
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Randomized Controlled Trial
Oral ENT-01 Targets Enteric Neurons to Treat Constipation in Parkinson Disease : A Randomized Controlled Trial.
Parkinson disease (PD) is associated with α-synuclein (αS) aggregation within enteric neurons. ENT-01 inhibits the formation of αS aggregates and improved constipation in an open-label study in patients with PD. ⋯ Enterin, Inc.
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Comment Meta Analysis
In the general population, salt substitutes vs. regular salt reduce BP levels, CV outcomes, and mortality.
Yin X, Rodgers A, Perkovic A, et al. Effects of salt substitutes on clinical outcomes: a systematic review and meta-analysis. Heart. 2022;108:1608-15. 35945000.
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It is important to document the performance of rapid antigen tests (Ag-RDTs) in detecting SARS-CoV-2 variants. ⋯ National Heart, Lung, and Blood Institute of the National Institutes of Health.
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The effectiveness of a third mRNA COVID-19 vaccine dose (booster dose) against the Omicron (B.1.1.529) variant is uncertain, especially in older, high-risk populations. ⋯ U.S. Department of Veterans Affairs.