Annals of internal medicine
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Review Meta Analysis
A Framework for the Development of Living Practice Guidelines in Health Care.
Living practice guidelines are increasingly being used to ensure that recommendations are responsive to rapidly emerging evidence. ⋯ None.
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Although the population-level differences between estimated glomerular filtration rate (eGFR) and measured glomerular filtration rate (mGFR) are well recognized, the magnitude and potential clinical implications of individual-level differences are unknown. ⋯ National Institutes of Health.
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Hepatitis C virus (HCV) infection can be cured, and the United States has joined the World Health Organization in calling for HCV elimination by 2030. However, historically low uptake of HCV treatment among people who inject drugs (PWID) threatens HCV elimination and exacerbates social and racial health disparities. ⋯ National Institutes of Health.
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Randomized Controlled Trial
Effect of Molnupiravir on Biomarkers, Respiratory Interventions, and Medical Services in COVID-19 : A Randomized, Placebo-Controlled Trial.
In the MOVe-OUT trial, molnupiravir showed a clinically meaningful reduction in the risk for hospitalization or death in adults with mild to moderate COVID-19 and risk factors for progression to severe disease. ⋯ Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc.
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Comment Meta Analysis
In diabetes, some statins reduce non-HDL-C better than others vs. placebo.
Hodkinson A, Tsimpida D, Kontopantelis E, et al. Comparative effectiveness of statins on non-high density lipoprotein cholesterol in people with diabetes and at risk of cardiovascular disease: systematic review and network meta-analysis. BMJ. 2022;376:e067731. 35331984.