Annals of internal medicine
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State medical cannabis laws may lead patients with chronic noncancer pain to substitute cannabis in place of prescription opioid or clinical guideline-concordant nonopioid prescription pain medications or procedures. ⋯ National Institute on Drug Abuse.
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Comment Randomized Controlled Trial
In moderately to severely active UC, etrasimod increased remission at 12 and 52 wk but increased adverse events.
Sandborn WJ, Vermeire S, Peyrin-Biroulet L, et al. Etrasimod as induction and maintenance therapy for ulcerative colitis (ELEVATE): two randomised, double-blind, placebo-controlled, phase 3 studies. Lancet. 2023;401:1159-1171. 36871574.
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Clinical practice guidelines recommend indefinite anticoagulation for a first unprovoked venous thromboembolism (VTE). ⋯ Canadian Institutes of Health Research.
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In previous studies, the prevalence of patent foramen ovale (PFO) has been reported to be higher in scuba divers who experienced decompression illness (DCI) than in those who did not. ⋯ Sejong Medical Research Institute.
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Comment Randomized Controlled Trial
In CAD, treat-to-target statins were noninferior to high-intensity statins for a composite clinical outcome.
Hong SJ, Lee YJ, Lee SJ, et al; LODESTAR Investigators. Treat-to-target or high-intensity statin in patients with coronary artery disease: a randomized clinical trial. JAMA. 2023;329:1078-1087. 36877807.