Annals of internal medicine
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Randomized Controlled Trial
Oral ENT-01 Targets Enteric Neurons to Treat Constipation in Parkinson Disease : A Randomized Controlled Trial.
Parkinson disease (PD) is associated with α-synuclein (αS) aggregation within enteric neurons. ENT-01 inhibits the formation of αS aggregates and improved constipation in an open-label study in patients with PD. ⋯ Enterin, Inc.
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Randomized Controlled Trial Multicenter Study
Medical Masks Versus N95 Respirators for Preventing COVID-19 Among Health Care Workers : A Randomized Trial.
It is uncertain if medical masks offer similar protection against COVID-19 compared with N95 respirators. ⋯ Canadian Institutes of Health Research, World Health Organization, and Juravinski Research Institute.
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Randomized Controlled Trial Multicenter Study
Total Ankle Replacement Versus Arthrodesis for End-Stage Ankle Osteoarthritis : A Randomized Controlled Trial.
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Randomized Controlled Trial Multicenter Study
Ticagrelor-Aspirin Versus Clopidogrel-Aspirin Among CYP2C19 Loss-of-Function Carriers With Minor Stroke or Transient Ischemic Attack in Relation to Renal Function: A Post Hoc Analysis of the CHANCE-2 Trial.
Evidence on the risk-benefit ratio of dual antiplatelet therapies among patients with stroke and impaired renal function is limited and inconsistent. ⋯ Ministry of Science and Technology of the People's Republic of China.
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Comment Randomized Controlled Trial Multicenter Study Pragmatic Clinical Trial
In acute ischemic stroke, early IV tenecteplase was noninferior to alteplase for excellent functional outcome.
Menon BK, Buck BH, Singh N, et al. Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial. Lancet. 2022;400:161-9. 35779553.