Annals of internal medicine
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Randomized Controlled Trial Multicenter Study
Grazoprevir-Elbasvir Combination Therapy for Treatment-Naive Cirrhotic and Noncirrhotic Patients With Chronic Hepatitis C Virus Genotype 1, 4, or 6 Infection: A Randomized Trial.
Novel interferon- and ribavirin-free regimens are needed to treat hepatitis C virus (HCV) infection. ⋯ Merck & Co.
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Randomized Controlled Trial Multicenter Study
Low-molecular-weight heparin for women with unexplained recurrent pregnancy loss: a multicenter trial with a minimization randomization scheme.
A daily injection of low-molecular-weight heparin (LMWH) is often prescribed to women with unexplained recurrent pregnancy loss (RPL), although evidence suggesting a benefit is questionable. ⋯ Pfizer Pharma.
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Randomized Controlled Trial Multicenter Study
Surgery versus nonsurgical treatment of lumbar spinal stenosis: a randomized trial.
Primary care management decisions for patients with symptomatic lumbar spinal stenosis (LSS) are challenging, and nonsurgical guidance is limited by lack of evidence. ⋯ National Institutes of Health and National Institute of Arthritis and Musculoskeletal and Skin Diseases.
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Multicenter Study Observational Study
Time-updated systolic blood pressure and the progression of chronic kidney disease: a cohort study.
Previous reports of the longitudinal association between achieved blood pressure (BP) and end-stage renal disease (ESRD) among patients with chronic kidney disease (CKD) have not incorporated time-updated BP with appropriate covariate adjustment. ⋯ National Institute of Diabetes and Digestive and Kidney Diseases.
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Multicenter Study
An analysis of calibration and discrimination among multiple cardiovascular risk scores in a modern multiethnic cohort.
Accurate risk assessment of atherosclerotic cardiovascular disease (ASCVD) is essential to effectively balance the risks and benefits of therapy for primary prevention. ⋯ National Heart, Lung, and Blood Institute.