Annals of internal medicine
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In the United States, costs of antidiabetes medications exceed $327 billion. ⋯ American College of Physicians. (PROSPERO: CRD42022382315).
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Time-restricted eating (TRE) lowers body weight in many studies. Whether TRE induces weight loss independent of reductions in calorie intake, as seen in rodent studies, is unknown. ⋯ American Heart Association.
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The American College of Physicians (ACP) developed this clinical guideline to update recommendations on newer pharmacologic treatments of type 2 diabetes. This clinical guideline is based on the best available evidence for effectiveness, comparative benefits and harms, consideration of patients' values and preferences, and costs. ⋯ ACP recommends against adding a dipeptidyl peptidase-4 (DPP-4) inhibitor to metformin and lifestyle modifications in adults with type 2 diabetes and inadequate glycemic control to reduce morbidity and all-cause mortality (strong recommendation; high-certainty evidence).
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The U.S. antibiotic market failure has threatened future innovation and supply. Understanding when and why clinicians underutilize recently approved gram-negative antibiotics might help prioritize the patient in future antibiotic development and potential market entry rewards. ⋯ U.S. Food and Drug Administration; NIH Intramural Research Program.
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The purpose of this visual clinical guideline is to provide a visual summary of ACP's clinical guideline, "Newer Pharmacologic Treatments in Adults With Type 2 Diabetes." In addition, this visual clinical guideline features an interactive data visualization of findings associated with ACP's clinical recommendations for this topic.