Annals of internal medicine
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Multicenter Study
A prospective assessment defining the limitations of thyroid nodule pathologic evaluation.
Clinical management of thyroid neoplasms is based on light microscopic diagnosis, but its accuracy and precision are poorly defined. ⋯ Veracyte.
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Randomized Controlled Trial Multicenter Study
Tofacitinib in combination with nonbiologic disease-modifying antirheumatic drugs in patients with active rheumatoid arthritis: a randomized trial.
Many patients with rheumatoid arthritis (RA) do not achieve adequate and safe responses with disease-modifying antirheumatic drugs (DMARDs). Tofacitinib is a novel, oral, Janus kinase inhibitor that treats RA. ⋯ Pfizer.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Salicylate (salsalate) in patients with type 2 diabetes: a randomized trial.
Short-duration studies show that salsalate improves glycemia in type 2 diabetes mellitus (T2DM). ⋯ Salsalate improves glycemia in patients with T2DM and decreases inflammatory mediators. Continued evaluation of mixed cardiorenal signals is warranted.
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Randomized Controlled Trial Multicenter Study Comparative Study
Aspirin versus low-molecular-weight heparin for extended venous thromboembolism prophylaxis after total hip arthroplasty: a randomized trial.
The role of aspirin in thromboprophylaxis after total hip arthroplasty (THA) is controversial. ⋯ Canadian Institutes of Health Research.
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Randomized Controlled Trial Multicenter Study
Treatment of idiopathic pulmonary fibrosis with ambrisentan: a parallel, randomized trial.
Idiopathic pulmonary fibrosis (IPF) is characterized by formation and proliferation of fibroblast foci. Endothelin-1 induces lung fibroblast proliferation and contractile activity via the endothelin A (ETA) receptor. ⋯ Gilead Sciences.