Annals of internal medicine
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Meta Analysis
Therapy for Helicobacter pylori in patients with nonulcer dyspepsia. A meta-analysis of randomized, controlled trials.
To assess the effect of eradication therapy for Helicobacter pylori on symptoms of nonulcer dyspepsia. ⋯ This meta-analysis provides little support for the use of H. pylori eradication therapy in patients with nonulcer dyspepsia.
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Review Meta Analysis
Osteoarthritis: new insights. Part 2: treatment approaches.
Osteoarthritis is the most common form of arthritis, affecting millions of people in the United States. It is a complex disease whose etiology bridges biomechanics and biochemistry. Evidence is growing for the role of systemic factors, such as genetics, diet, estrogen use, and bone density, and local biomechanical factors, such as muscle weakness, obesity, and joint laxity. ⋯ Part 2 focuses on treatment approaches; evidence for the efficacy of commonly used oral therapies is reviewed and information on alternative therapies, including nutriceuticals and acupuncture, is presented. Biomechanical interventions, such as exercise and bracing, and behavioral interventions directed toward enhancing self-management are reviewed. Current surgical approaches are described and probable future biotechnology-oriented approaches to treatment are suggested.
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Meta Analysis Comparative Study
Single-therapy androgen suppression in men with advanced prostate cancer: a systematic review and meta-analysis.
To compare luteinizing hormone-releasing hormone (LHRH) agonists with orchiectomy or diethylstilbestrol, and to compare antiandrogens with any of these three alternatives. ⋯ Survival after therapy with an LHRH agonist was equivalent to that after orchiectomy. No evidence shows a difference in effectiveness among the LHRH agonists. Survival rates may be somewhat lower if a nonsteroidal antiandrogen is used as monotherapy.
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To review the literature on prevention of intravascular catheter-related infections. ⋯ Simple interventions can reduce the risk for serious catheter-related infection. Adequately powered randomized trials are needed.
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Meta Analysis Comparative Study
Low-molecular-weight heparins compared with unfractionated heparin for treatment of acute deep venous thrombosis. A cost-effectiveness analysis.
Low-molecular-weight heparins are effective for treating venous thrombosis, but their cost-effectiveness has not been rigorously assessed. ⋯ Low-molecular-weight heparins are highly cost-effective for inpatient management of venous thrombosis. This treatment reduces costs when small numbers of patients are eligible for outpatient management.